Skype is one of the most popular video conferencing apps in the world. If you use one of the best Chromebooks as your daily device for work or school or have installed ChromeOS on a non-Chromebook device, you'll probably want to run Skype. In addition to calls for business, you can also use Skype as a messenger service to keep in touch with family and friends. While Skype doesn't offer a native ChromeOS app, there are several viable options to run Skype on a Chromebook.